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Article

Disturbed Spatial WNT Activation-A Potential Driver of the Reticularized Skin Phenotype in Systemic Sclerosis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2025

Fakhouri Sara Chenguiti, Zhu Honglin, Li Yi-Nan, Ronicke Moritz, Rigau Aleix Rius, Dees Clara, Konstantinidis Laura, Schmid Ralf, Matei Alexandru-Emil, Eckstein Markus, Geppert Carol, Ludolph Ingo, Kreuter Alexander, Sticherling Michael, Berking Carola, Horch Raymund E, Schett Georg, Distler Jörg H W, Bergmann Christina

Abstract excerpt

OBJECTIVE: Little is known on the mechanisms necessary to maintain the physiologic adult human skin integrity. This study aims to quantitatively describe anatomic changes in systemic sclerosis (SSc)-skin compared with controls and investigate the underlying mechanisms. METHODS: Skin morphology was histologically assessed in 23 patients with SSc, 18 controls, and 15 patients with hypertrophic scars. Spatial...

Read the complete abstract on PubMed

Topics

Humans
Scleroderma, Systemic
Skin
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Wnt Signaling Pathway

Fibroblasts

Adult

Phenotype

Axin Protein

Cicatrix, Hypertrophic

Aged

Case-Control Studies

beta Catenin

Source

Open in PubMed Open full text

Identifiers

PMID: 39722197
DOI: 10.1002/art.43094
PMCID: PMC12123256

Genes

AXIN2
PI16
SFRP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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