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Article

Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases.

International journal of molecular sciences - 18 Sept 2025

Lazanas Panagiotis, Antonatos Charalabos, Tsoumani Konstantina T, Sgourou Argyro, Vasilopoulos Yiannis

Abstract excerpt

Atopic dermatitis (AD) and autoimmune diseases exhibit epidemiological comorbidity, yet the shared genetic architecture remains incompletely understood. We investigated the genetic overlap between AD and three autoimmune disorders including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and vitiligo, leveraging genome-wide association data. Despite modest evidence for global genetic correlations, we...

Read the complete abstract on PubMed

Topics

Humans
Dermatitis, Atopic
Genome-Wide Association Study
Autoimmune Diseases
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Vitiligo

Inflammatory Bowel Diseases

Mendelian Randomization Analysis

Genetic Pleiotropy

Arthritis, Rheumatoid

Source

Open in PubMed Open full text

Identifiers

PMID: 41009683
DOI: 10.3390/ijms26189124
PMCID: PMC12470386

Genes

DOK2
GPR132
SUOX
TNFRSF11A
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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