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Article

The Mla pathway promotes Vibrio cholerae re-expansion from stationary phase.

mBio - 5 Feb 2025

Leitner Deborah R, Zingl Franz G, Morano Alexander A, Zhang Hailong, Waldor Matthew K

Abstract excerpt

Bacteria have evolved diverse strategies to ensure survival under nutrient-limited conditions, where rapid energy generation is not achievable. Here, we performed a transposon insertion site sequencing loss-of-function screen to identify Vibrio cholerae genes that promote pathogen fitness in stationary phase. We discovered that the maintenance of lipid asymmetry (Mla) pathway, which is crucial for transferring...

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PMID: 39714184
DOI: 10.1128/mbio.03433-24
PMCID: PMC11796348

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