Vibrio deploys Type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

Abstract excerpt

Pathogens find diverse niches for survival inside host cells where replication occurs in a relatively protected environment. Vibrio parahaemolyticus, a facultative intracellular pathogen, uses its type 3 secretion system 2 (T3SS2) to invade and replicate inside host cells. However, after extensive analysis, the T3SS2 pathogenicity island appeared to lack a mechanism for egress of this bacterium from the invaded h...

Topics

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• Antimicrobial Resistance in Staphylococcus
• Bacterial Adhesion
• Biofilms
• Gene Expression Regulation, Bacterial
• Macrophages
• Mice, Inbred BALB C
• Microbial infections and disease research
• Streptococcal Infections and Treatments

Identifiers and source

Literature Corpus work

a93bc32d-b37a-545a-9ec4-de6c27a17a77

DOI

10.1101/835777