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Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

6 Dec 2024

Abstract excerpt

Ceftazidime–avibactam (CZA) is one of the effective antibiotics used for the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but its resistance rate has increased recently. Previous studies have focused on the mechanisms of CZA resistance, while its heteroresistance in CRKP remains poorly understood. This study aimed to investigate the characteristics and mechanisms of CZA...

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PMID: 39711783
DOI: 10.3389/fcimb.2024.1450530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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