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Article

Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells

1 Jun 2017

Abstract excerpt

Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1α and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone H3 lysine) at promoters of target genes, leading to the aerobic glycolysis inhibition and cell growth suppression. However, its expression has recently been reported to be...

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PMID: 28653878
DOI: 10.1177/1010428317708532

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