Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sevoflurane aggravated neuroinflammation and oxidative stress in neonatal mice by modulating microglia phenotype via circRNA2092/miR-873a-5p/KEAP1.

Neurotoxicology - 1 Mar 2026

Li Yanan, Du Juan, Zhang Jiajie, Cai Zhenzhen, Shi Lei, Liang Jia, Zhang Qi

Abstract excerpt

Repeat sevoflurane exposure can cause developmental neurotoxicity while its underlying mechanism is still ambiguous. Contemporary research has increasingly highlighted the regulatory role of non-coding RNAs (ncRNAs) in the development of neurological diseases, particularly neurodegenerative conditions. However, the potential involvement of ncRNAs in sevoflurane-induced neurotoxicity remains poorly understood. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthetics, Inhalation
Share to Animals, Newborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kelch-Like ECH-Associated Protein 1

Share to Microglia

Share to MicroRNAs

Share to Neuroinflammatory Diseases

Share to Oxidative Stress

Share to RNA, Circular

Source

Identifiers

PMID: 41759746
DOI: 10.1016/j.neuro.2026.103410

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sevoflurane aggravated neuroinflammation and oxidative stress in neonatal mice by modulating microglia phenotype via circRNA2092/miR-873a-5p/KEAP1.PMID 41759746Read ↗

Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged miceSemantic proximity Read ↗

Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1/Nrf2 signaling axis in aged ratsSemantic proximity Read ↗

The mmu_circ_0000335 inhibits M1 microglial-induced hippocampal neuronal apoptosis via the miR-19b-3p/SOCS1 axis in a mouse epilepsy modelSemantic proximity Read ↗

Emerging Role of Long Noncoding RNAs in Perioperative Neurocognitive Disorders and Anesthetic-Induced Developmental NeurotoxicitySemantic proximity Read ↗

Repeated Neonatal Sevoflurane Induced Neurocognitive Impairment Through NF-κB-Mediated PyroptosisSemantic proximity Read ↗

Rosiglitazone promotes oligodendrocyte development and myelin formation of repeated neonatal sevoflurane exposure via PPARγ signalingSemantic proximity Read ↗

Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunctionSemantic proximity Read ↗

Accumulation of Lipid Droplets in Microglia following Neonatal Brain Hypoxia-IschemiaSemantic proximity Read ↗

Single-cell Transcriptomic Profiling of Brains in Newborn Rats Following Hypoxic Ischemic EncephalopathySemantic proximity Read ↗

Effect of histone demethylase KDM5B on long-term cognitive impairment in neonatal rats induced by sevofluraneSemantic proximity Read ↗

Propofol Alters Long Non-Coding RNA Profiles in the Neonatal Mouse Hippocampus: Implication of Novel Mechanisms in Anesthetic-Induced Developmental NeurotoxicitySemantic proximity Read ↗

RETRACTED: Exploring causative gene and pathway of sevoflurane-induced anesthetic effects and implication on nervous system diseases based on high-throughput scRNA-seq dataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.