Article
Genetically Determined Smoking Behavior and Risk of Nontraumatic Subarachnoid Hemorrhage.
Stroke - 1 Jan 2021
Acosta Julián N, Szejko Natalia, Both Cameron P, Vanent Kevin, Noche Rommell B, Gill Thomas M, Matouk Charles C, Sheth Kevin N, Gunel Murat, Falcone Guido J
Abstract excerpt
BACKGROUND AND PURPOSE: Animal and observational studies indicate that smoking is a risk factor for aneurysm formation and rupture, leading to nontraumatic subarachnoid hemorrhage (SAH). However, a definitive causal relationship between smoking and the risk of SAH has not been established. Using Mendelian randomization (MR) analyses, we tested the hypothesis that smoking is causally linked to the risk of SAH....
Topics
- Adult
- Aged
- Databases, Factual
- Electronic Health Records
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Intracranial Aneurysm
- Male
- Mendelian Randomization Analysis