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Article

Regulation of enteric vapBC transcription: induction by VapC toxin dimer-breaking.

Nucleic acids research - 1 May 2012

Winther Kristoffer S, Gerdes Kenn

Abstract excerpt

Toxin-antitoxin (TA) loci encode inhibitors of translation, replication or cell wall synthesis and are common elements of prokaryotic plasmids and chromosomes. Ten TA loci of Escherichia coli K-12 encode mRNases that cumulatively contribute to persistence (multidrug tolerance) of the bacterial cells. The mechanisms underlying induction and reversion of the persistent state are not yet understood. The vapBC operon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22287572
DOI: 10.1093/nar/gks029
PMCID: PMC3378870

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