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Article

Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway.

Molecular medicine (Cambridge, Mass.) - 19 Dec 2024

Lee Sheunghun, Lee Hyerim, Jang You-Jee, Lee Kyubin, Kim Hye-Jung, Lee Jung Yeol, Kim Jin-Man, Park Sunyou, Song Jin Sook, Lee Ji Hoon, Hyun Tae Kyung, Park Jae-Il, Yi Sun-Ju, Kim Kyunghwan

Abstract excerpt

BACKGROUND: Bone remodeling is a critical process that maintains skeletal integrity, orchestrated by the balanced activities of osteoclasts, which resorb bone, and osteoblasts, which form bone. Osteoclastogenesis, the formation of osteoclasts, is primarily driven by NFATc1, a process activated through c-Fos and NF-κB signaling pathways in response to receptor activator of nuclear factor κB ligand (RANKL)....

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Identifiers

PMID: 39701944
DOI: 10.1186/s10020-024-01031-2
PMCID: PMC11660935

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