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Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue

26 Dec 2023

Abstract excerpt

Macrophages populate the embryo early in gestation, but their role in development is not well defined. In particular, specification and function of macrophages in intestinal development remain little explored. To study this event in the human developmental context, we derived and combined human intestinal organoid and macrophages from pluripotent stem cells. Macrophages migrate into the organoid, proliferate, and...

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PMID: 38150367
DOI: 10.1016/j.celrep.2023.113616

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