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Article

NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9.

Journal of cardiovascular translational research - 1 Apr 2025

Yin Wei, Wang Jie, Li Lingling, Zheng Hongyun, Xu Shengkai

Abstract excerpt

Atherosclerosis (AS) is an inflammatory disease affected by macrophage polarization. N4-acetylcytosine (ac4C) modification mediated by N-acetyltransferase 10 (NAT10). In this study, we aimed to elucidate the role of ac4C modification mediated macrophage polarization in AS through in vivo and in vitro experiments. The ac4C level was measured using dot blot. Macrophage polarization was assessed by quantitative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Macrophage Activation

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Share to Plaque, Atherosclerotic

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Source

Identifiers

PMID: 39699778
DOI: 10.1007/s12265-024-10579-7

Genes

NAT10
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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