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Article

Bistability in a model of tumor-immune system interactions with an oncolytic viral therapy

1 Jan 2021

Abstract excerpt

A mathematical model of tumor-immune system interactions with an oncolytic virus therapy for which the immune system plays a twofold role against cancer cells is derived. The immune cells can kill cancer cells but can also eliminate viruses from the therapy. In addition, immune cells can either be stimulated to proliferate or be impaired to reduce their growth by tumor cells. It is shown that if the tumor killing...

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PMID: 35135217
DOI: 10.3934/mbe.2022072

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