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Article

Physiologically based pharmacokinetic (PBPK) modelling of tamsulosin related to CYP2D6*10 allele.

Archives of pharmacal research - 1 Nov 2021

Cho Chang-Keun, Kang Pureum, Park Hye-Jung, Lee Yun Jeong, Bae Jung-Woo, Jang Choon-Gon, Lee Seok-Yong

Abstract excerpt

Tamsulosin, a selective [Formula: see text]-adrenoceptor blocker, is commonly used for alleviation of lower urinary tract symptoms related to benign prostatic hyperplasia. Tamsulosin is predominantly metabolized by CYP3A4 and CYP2D6 enzymes, and several studies reported the effects of CYP2D6 genetic polymorphism on the pharmacokinetics of tamsulosin. This study aims to develop and validate the physiologically...

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PMID: 34751931
DOI: 10.1007/s12272-021-01357-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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