Integration of biological data via NMF for identification of human disease-associated gene modules through multi-label classification.

Abstract excerpt

Proteins associated with multiple diseases often interact, forming disease modules that are critical for understanding disease mechanisms. This study integrates protein-protein interactions (PPIs) and Gene Ontology data using non-negative matrix factorization (NMF) to identify gene modules associated with human diseases. We leverage two biological sources of information, protein-protein interactions (PPIs) and...

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