Article
Co-clustering phenome-genome for phenotype classification and disease gene discovery.
Nucleic acids research - 1 Oct 2012
Hwang TaeHyun, Atluri Gowtham, Xie MaoQiang, Dey Sanjoy, Hong Changjin, Kumar Vipin, Kuang Rui
Abstract excerpt
Understanding the categorization of human diseases is critical for reliably identifying disease causal genes. Recently, genome-wide studies of abnormal chromosomal locations related to diseases have mapped >2000 phenotype-gene relations, which provide valuable information for classifying diseases and identifying candidate genes as drug targets. In this article, a regularized non-negative matrix tri-factorization...
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