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Article

Biomarker discovery by integrated joint non-negative matrix factorization and pathway signature analyses.

Scientific reports - 27 Jun 2018

Fujita Naoya, Mizuarai Shinji, Murakami Katsuhiko, Nakai Kenta

Abstract excerpt

Predictive biomarkers are important for selecting appropriate patients for particular treatments. Comprehensive genomic, transcriptomic, and pharmacological data provide clues for understanding relationships between biomarkers and drugs. However, it is still difficult to mine biologically meaningful biomarkers from multi-omics data. Here, we developed an approach for mining multi-omics cell line data by...

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Identifiers

PMID: 29950679
DOI: 10.1038/s41598-018-28066-w
PMCID: PMC6021419

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