lncRNA-disease association prediction based on optimizing measures of multi-graph regularized matrix factorization.

Abstract excerpt

In this paper, we propose a novel lncRNA-disease association prediction algorithm based on optimizing measures of multi-graph regularized matrix factorization (OM-MGRMF). The method first calculates the semantic similarity of diseases, the functional similarity of lncRNAs, and the Gaussian similarity of both. It then constructs a new lncRNA-disease association matrix by using the K-nearest-neighbor (KNN)...

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