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Fast analysis of biobank-size data and meta-analysis using the BGLR R-package.

G3 (Bethesda, Md.) - 17 Apr 2025

Pérez-Rodríguez Paulino, de Los Campos Gustavo, Wu Hao, Vazquez Ana I, Jones Kyle

Abstract excerpt

Analyzing human genomic data from biobanks and large-scale genetic evaluations often requires fitting models with a sample size exceeding the number of DNA markers used (n>p). For instance, developing polygenic scores for humans and genomic prediction for genetic evaluations of agricultural species may require fitting models involving a few thousand SNPs using data with hundreds of thousands of samples. In such...

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PMID: 39657738
DOI: 10.1093/g3journal/jkae288
PMCID: PMC12005161

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