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Article

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases.

Journal of visualized experiments : JoVE - 22 Nov 2024

Choudhury Himashree, Sharma Manish, Gangwar Utkarsh, Siddiqui Nayla, Bansal Abhisheka

Abstract excerpt

One of the mechanisms for subverting the effect of drugs by the malaria parasite is through rewiring of its transcriptome. The effect is more pronounced for target genes belonging to the multigene family. Plasmodium falciparum protein kinases belonging to the CDPK family are essential for blood stage development. As such, CDPKs are considered good targets for the development of anti-malarial compounds. The...

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PMID: 39651747
DOI: 10.3791/67079

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