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An evolutionary perspective on the kinome of malaria parasites

13 Aug 2012

Abstract excerpt

Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL, CaMK and CK1 groups found in yeast, plants and mammals, testifying to the ancient ancestry of these families. However, several hundred millions years of independent...

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PMID: 22889911
DOI: 10.1098/rstb.2012.0014

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