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Spatial transcriptomics identifies RBM39 as a gene associated with Gleason score progression in prostate cancer

9 Nov 2024

Abstract excerpt

Prostate cancer (PCa) exhibits significant intratumor heterogeneity, frequently manifesting as a multifocal disease. This study utilized Visium spatial transcriptomics (ST) to explore transcriptome patterns in PCa regions with varying Gleason scores (GSs). Principal component analysis (PCA) and Louvain clustering analysis revealed transcriptomic classifications aligned with the histology of different GSs. The...

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PMID: 39650727
DOI: 10.1016/j.isci.2024.111351

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