Article
A genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt/β-catenin signaling pathways.
Journal of the American Academy of Dermatology - 1 Apr 2025
Kjærsgaard Andersen Rune, Stefansdottir Lilja, Riis Peter Theut, Halldorsson Gisli, Ferkingstad Egil, Oddsson Asmundur, Walters Bragi, Olafsdottir Thorunn A, Rutsdottir Gudrun, Zachariae Claus, Thomsen Simon Francis, Brodersen Thortsen, Dinh Khoa Manh, Knowlton Kirk U, Knight Stacey, Nadauld Lincoln D, Banasik Karina, Brunak Søren, Hansen Thomas Folkmann, Hjalgrim Henrik, Sørensen Erik, Mikkelsen Chirstina, Ullum Henrik, Nyegaard Mette, Bruun Mie Topholm, Erikstrup Christian, Ostrowski Sisse Rye, Eidsmo Liv, Saunte Ditte Marie Lindhardt, Sigurgeirsson Bárdur, Orvar Kjartar B, Saemundsdottir Jona, Melsted Pall, Norddahl Gudmundur L, Sulem Patrick, Stefansson Hreinn, Holm Hilma, Gudbjartsson Daniel, Thorleifsson Gudmar, Jonsdottir Ingileif, Pedersen Ole Birger Vesterager, Jemec Gregor Borut Ernst, Stefansson Kari
Abstract excerpt
BACKGROUND: The contributions of genetic and environmental risk factors to hidradenitis suppurativa (HS) are both poorly understood. OBJECTIVE: To identify sequence variants that associate with HS and determine the contribution of environmental risk factors and inflammatory diseases to HS pathogenesis. METHODS: A genome-wide association meta-analysis of 4814 HS cases (Denmark: 1977; Iceland: 1266; Finland: 800;...
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