Article

The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling

2025-07-28

Abstract excerpt

We sought to identify clinically relevant regulators of hair follicle inflammation by conducting a human genetic study of hidradenitis suppurativa (HS), a prevalent, understudied, inflammatory disease with limited effective treatments. We performed a GWAS with 6,300 cases and identified 12 independent risk loci. Epigenetic and transcriptomic analyses of HS risk variants defined cell-specific gene regulatory progra...

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Literature Corpus work: 997447be-7549-52ac-b876-88df06f6e014
DOI: 10.1101/2025.07.25.25332168

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