Article
A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa.
The British journal of dermatology - 1 Oct 2017
Frew J W, Vekic D A, Woods J, Cains G D
Abstract excerpt
Hidradenitis suppurativa (HS) is a severe chronic inflammatory disorder characterized by recurrent painful deep-seated nodules with a predilection to the apocrine-bearing areas of skin. A minority of cases of HS are due to mutations in the γ-secretase complex. Contention exists surrounding the pathogenicity of sequence variants and their effects upon Notch signalling. This systematic review was registered with...
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