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Article

Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa.

The British journal of dermatology - 17 Oct 2025

Broadaway K Alaine, Sun Quan, Edmiston Sharon N, Currin Kevin W, Vadlamudi Swarooparani, Miller-Fleming Tyne W, Shi Yue, Fajgenbaum Kristen, Melendez-Gonzalez Maria, Bui Helen, Blum Franklin R, Westerkam Linnea, Shams Rayad, Mallela Teja, Levitt Brandt, Lin Lan, Hao Honglin, Memili Aylin, Straub Peter, Zhou Wei, Harris Kathleen Mullan, Martin Alicia, Cox Nancy J, Liu Zhi, Thomas Nancy E, Li Yun, Mohlke Karen L, Sayed Christopher J

Abstract excerpt

BACKGROUND: Hidradenitis suppurativa (HS) is a common, chronic and debilitating inflammatory disease that most commonly affects intertriginous skin. Despite its high heritability, the genetic underpinnings of HS remain poorly understood. OBJECTIVES: To identify genetic signals associated with HS, determine genetic relationships with other diseases and investigate potential molecular genetic mechanisms. METHODS:...

Topics

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SOX9 gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Hidradenitis Suppurativa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kruppel-Like Transcription Factors

Polymorphism, Single Nucleotide

Quantitative Trait Loci

SOX9 Transcription Factor

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Open in PubMed Open full text

Identifiers

PMID: 40650879
DOI: 10.1093/bjd/ljaf277
PMCID: PMC12279254

Genes

KLF5
SOX9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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