Article
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.
Nature neuroscience - 1 Sept 2018
Pasman Joëlle A, Verweij Karin J H, Gerring Zachary, Stringer Sven, Sanchez-Roige Sandra, Treur Jorien L, Abdellaoui Abdel, Nivard Michel G, Baselmans Bart M L, Ong Jue-Sheng, Ip Hill F, van der Zee Matthijs D, Bartels Meike, Day Felix R, Fontanillas Pierre, Elson Sarah L, de Wit Harriet, Davis Lea K, MacKillop James, Derringer Jaime L, Branje Susan J T, Hartman Catharina A, Heath Andrew C, van Lier Pol A C, Madden Pamela A F, Mägi Reedik, Meeus Wim, Montgomery Grant W, Oldehinkel A J, Pausova Zdenka, Ramos-Quiroga Josep A, Paus Tomas, Ribases Marta, Kaprio Jaakko, Boks Marco P M, Bell Jordana T, Spector Tim D, Gelernter Joel, Boomsma Dorret I, Martin Nicholas G, MacGregor Stuart, Perry John R B, Palmer Abraham A, Posthuma Danielle, Munafò Marcus R, Gillespie Nathan A, Derks Eske M, Vink Jacqueline M
Abstract excerpt
Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant...
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