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Article

Mendelian randomization study on the association of circulating ketone bodies with lung cancer and respiratory diseases.

Scientific reports - 4 Dec 2024

Tang Xisha, Zhuang Huijia, Yu Hai

Abstract excerpt

The liver produces various ketone bodies (KBs) including 3-Hydroxybutyrate (3-OHB), acetoacetate (AcAc), and acetone, with 3-OHB being the major component. Previous studies have shown that KBs protect against respiratory diseases; however, there is no evidence of a genetic link. To avoid biases existing in traditional observational studies, a two-sample Mendelian randomization (MR) analysis was carried out to...

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PMID: 39632975
DOI: 10.1038/s41598-024-81591-9
PMCID: PMC11618345

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