Article
Role of interleukin 6-174G>C polymorphism in primary open-angle glaucoma.
European journal of ophthalmology - 1 Jan 2000
Zimmermann Christina, Weger Martin, Faschinger Christoph, Renner Wilfried, Mossböck Georg
Abstract excerpt
PURPOSE: In addition to its proinflammatory effects, interleukin (IL)-6 also possesses antiapoptotic properties. Recently, IL-6 has been reported to protect retinal ganglion cells from pressure-induced apoptosis, indicating a possible role in the pathogenesis of primary open-angle glaucoma (POAG). A common polymorphism in the promoter region of IL-6 gene at position -174 characterized by a substitution from G to...
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