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Within-host Mycobacterium tuberculosis diversity and its utility for inferences of transmission

1 Oct 2018

Abstract excerpt

Whole genome sequencing in conjunction with traditional epidemiology has been used to reconstruct transmission networks of Mycobacterium tuberculosis during outbreaks. Given its low mutation rate, genetic diversity within M. tuberculosis outbreaks can be extremely limited - making it difficult to determine precisely who transmitted to whom. In addition to consensus SNPs (cSNPs), examining heterogeneous alleles...

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PMID: 30303479
DOI: 10.1099/mgen.0.000217

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