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Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis.

Immunogenetics - 30 Nov 2024

Santiesteban-Lores Lazara Elena, Midon Leonardo Moura, Franco ThirsaAlvares, de Oliveira Luciano Marcondes, Hibi Sumire, Chiani Yosena, Meneses GdayllonCavalcante, De Francesco Daher Elizabeth, Fonseca Denise Moraes, Pontillo Alessandra, Isaac Lourdes

Abstract excerpt

Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Leptospira infection is a multifactorial trait, and the host's genetic background can influence both the establishment of infection and the severity of the disease. Complement Factor H (FH) plays a crucial role in the interaction between pathogenic bacteria and the host. Genetic variants in the FH...

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PMID: 39614881
DOI: 10.1007/s00251-024-01362-8

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