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Article

Macrophage migration inhibitory factor gene promoter polymorphism (-173G/C SNP) determines host susceptibility and severity of leptospirosis.

Microbial pathogenesis - 1 Mar 2022

Sumaiya Krishnamoorthi, Natarajaseenivasan Kalimuthusamy

Abstract excerpt

The biological mechanisms that are associated with the severity of leptospirosis are far from complete. The aim of the present study was to investigate whether the macrophage migration inhibitory factor (MIF) gene promoter polymorphisms determine susceptibility to and severity of human leptospirosis. MIF is a potent pro-inflammatory cytokine, which has been reported to correlate with the risk of inflammatory...

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PMID: 35151822
DOI: 10.1016/j.micpath.2022.105445

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