Article
The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation.
Cancer - 1 Jan 2025
Katona Bryson W, Lubinski Jan, Pal Tuya, Huzarski Tomasz, Foulkes William D, Moller Pal, Eisen Andrea, Randall Armel Susan, Neuhausen Susan L, Raj Rebecca, Aeilts Amber, Singer Christian F, Bordeleau Louise, Karlan Beth, Olopade Olufunmilayo, Tung Nadine, Zakalik Dana, Kotsopoulos Joanne, Fruscio Robert, Eng Charis, Sun Ping, Narod Steven A
Abstract excerpt
BACKGROUND: The lifetime risk of pancreatic cancer in women with a germline mutation in BRCA1 and BRCA2 is not well established. In an international prospective cohort of female carriers of BRCA1 and BRCA2 mutations, the cumulative incidence of pancreatic cancer from age 40 until 80 years was estimated. METHODS: A total of 8295 women with a BRCA1 or BRCA2 mutation were followed for new cases of pancreatic cancer....
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