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Multidimensional characterization of the tumor microenvironment profiles in lung squamous cell carcinoma.

Physiological genomics - 1 Aug 2025

Zhou Yi, Chai Lixun, Wang Yuyao, Zhang Hongguang

Abstract excerpt

Tumor microenvironment (TME) plays an important role in tumorigenesis, development, metastasis, and drug sensitivity, but little is known about it in lung squamous cell carcinoma (LUSC). Here, the RNA-sequencing data, clinical and survival data of patients with LUSC in The Cancer Genome Atlas, and six independent datasets were collected. Based on the unsupervised clustering of knowledge-based functional gene...

Topics

Humans
Tumor Microenvironment
Lung Neoplasms
Carcinoma, Squamous Cell
Gene Expression Regulation, Neoplastic
Prognosis
Gene Expression Profiling
Mutation
Male
Female
Transcriptome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cluster Analysis

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Identifiers

PMID: 40560629
DOI: 10.1152/physiolgenomics.00042.2025

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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