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Article

Correlation between gene expression and mutator phenotype predicts homologous recombination deficiency and outcome in ovarian cancer.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2014

Lu Jianping, Wu Di, Li Chuanxing, Zhou Meng, Hao Dapeng

Abstract excerpt

UNLABELLED: New strategies are needed to predict response to platinum-based chemotherapy and outcome of ovarian cancers. We hypothesized that the mutator phenotype in the cancer genome represents the overuse of alternative DNA repair mechanisms, which might be a sign of homologous recombination (HR) deficiency and can be captured by gene expression. Multidimensional data of ovarian cancer patients and breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25062964
DOI: 10.1007/s00109-014-1191-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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