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Article

Molecular Subgroups of HRD Positive Ovarian Cancer and Their Prognostic Significance.

International journal of molecular sciences - 18 Dec 2024

Kekeeva Tatiana, Dudina Irina, Andreeva Yulia, Tanas Alexander, Kalinkin Alexey, Musatova Victoria, Chernorubashkina Natalia, Khokhlova Svetlana, Tikhomirova Tatiana, Volkonsky Mikhail, Kutsev Sergey, Zaletaev Dmitry, Strelnikov Vladimir

Abstract excerpt

Homologous recombination repair deficiency (HRD) is involved in the development of high-grade serous ovarian carcinoma (HGSOC) and its elevated sensitivity to platinum-based chemotherapy. To investigate the heterogeneity of the HRD-positive HGSOC we evaluated the HRD status, including BRCA mutations, genomic scar score, and methylation status of BRCA1/2 genes in 352 HGSOC specimens. We then divided the...

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PMID: 39769312
DOI: 10.3390/ijms252413549

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