Article
NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011
Zhao Jimmy L, Rao Dinesh S, Boldin Mark P, Taganov Konstantin D, O'Connell Ryan M, Baltimore David
Abstract excerpt
MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts, showing that they are true malignancies. The animals also exhibit chronic myeloproliferation in their bone marrow....
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