Article
[Search for risk genes in Alzheimer's disease].
Der Nervenarzt - 1 Jul 2017
Karaca I, Wagner H, Ramirez A
Abstract excerpt
Alzheimer's disease (AD) is the most common form of neurodegenerative dementia. The susceptibility to AD is determined by a complex interaction between genetic, epigenetic, and environmental factors. Herein, the risk that can be attributed to genetic factors is high (up to 80%). While most AD patients are sporadic, in rare families Mendelian mode of inheritance can be observed. In these rare familial cases, full...
Topics
- Alzheimer Disease
- DNA Mutational Analysis
- Endophenotypes
- Epigenesis, Genetic
- Gene-Environment Interaction
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Penetrance
- Risk Factors