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Article

Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis.

Autophagy - 1 Jan 2015

Kim Myungjin, Semple Ian, Kim Boyoung, Kiers Alexandra, Nam Samuel, Park Hwan-Woo, Park Haeli, Ro Seung-Hyun, Kim Jeong-Sig, Juhász Gábor, Lee Jun Hee

Abstract excerpt

Autophagy is an essential process for eliminating ubiquitinated protein aggregates and dysfunctional organelles. Defective autophagy is associated with various degenerative diseases such as Parkinson disease. Through a genetic screening in Drosophila, we identified CG11148, whose product is orthologous to GIGYF1 (GRB10-interacting GYF protein 1) and GIGYF2 in mammals, as a new autophagy regulator; we hereafter...

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Source

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Identifiers

PMID: 26086452
DOI: 10.1080/15548627.2015.1063766
PMCID: PMC4590642

Genes

GIGYF2
GRB10
GIGYF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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