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Phenotypes and Trajectories of Tobacco-exposed Persons with Preserved Spirometry: Insights from Lung Volumes.

Annals of the American Thoracic Society - 1 Apr 2025

Arjomandi Mehrdad, Zeng Siyang, Barjaktarevic Igor, Bleecker Eugene R, Bowler Russell P, Criner Gerard J, Comellas Alejandro P, Couper David J, Curtis Jeffrey L, Dransfield Mark T, Drummond M Bradley, Fortis Spyridon, Han MeiLan K, Hansel Nadia N, Hoffman Eric A, Kaner Robert J, Kanner Richard E, Krishnan Jerry A, Labaki Wassim, Ortega Victor E, Peters Stephen P, Rennard Stephen I, Cooper Christopher B, Tashkin Donald P, Paine Robert, Woodruff Prescott G

Abstract excerpt

Rationale: Among tobacco-exposed persons with preserved spirometry (TEPSs), we previously demonstrated that different lung volume indices-specifically, elevated total lung capacity (TLC) versus elevated ratio of functional residual capacity to TLC (FRC/TLC)-identify different lung disease characteristics in the COPDGene cohort. Objective: We sought to determine differential disease characteristics and...

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Disease Progression
Forced Expiratory Volume
Lung
Pulmonary Disease, Chronic Obstructive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Emphysema

Tomography, X-Ray Computed

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PMID: 39586032
DOI: 10.1513/AnnalsATS.202405-527OC
PMCID: PMC12005044

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