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Divergent prognostic roles of air trapping and reduced inspiratory reserve in COPD: Exacerbations versus functional decline.

Respiratory medicine - 1 Sept 2026

Kang Hye-Rin, Song Jin Hwa, Park Shinhee, Ra Seung Won, Lee Chang Youl, Hwang Yong Il, Kim Deog Kyeom, Lee Jin Hwa, Yoo Kwang Ha, Kim Youlim

Abstract excerpt

BACKGROUND: Lung hyperinflation is a key feature of COPD, yet it remains unclear if its primary components-reduced inspiratory reserve (IC/TLC) and air trapping (RV/TLC)-predict distinct clinical trajectories. We investigated the independent prognostic roles of these indices regarding acute exacerbations and functional decline. METHODS: We analyzed 1214 COPD patients from the prospective KOCOSS cohort. Patients...

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Disease Progression
Exercise Tolerance
Forced Expiratory Volume
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Pulmonary Disease, Chronic Obstructive

Respiratory Function Tests

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PMID: 42314775
DOI: 10.1016/j.rmed.2026.108978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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