Genetic risk factors for Mesoamerican nephropathy.

doi:10.1073/pnas.2404848121

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Article

Genetic risk factors for Mesoamerican nephropathy.

Proceedings of the National Academy of Sciences of the United States of America - 3 Dec 2024

Friedman David J, Leone Dominick A, Amador Juan José, Kupferman Joseph, Francey Lauren J, Lopez-Pilarte Damaris, Lau Jorge, Delgado Iris, Yih W Katherine, Salinas Alejandro, Wang Minxian, Genovese Giulio, Shah Shrijal, Kelly Jessica, Tattersfield Calum F, Raines Nathan H, Amador Magaly, Dias Leny, Pitsillides Achilleas, Ramirez-Rubio Oriana, Amador Alda G, Cortopassi Marissa, Applebaum Katie M, Alper Seth L, Banks Alex S, McClean Michael D, Leibler Jessica H, Scammell Madeleine K, Dupuis Josée, Brooks Daniel R

Abstract excerpt

Mesoamerican nephropathy (MeN) is a progressive kidney disease found on the Pacific coast of Central America primarily in young male agricultural workers without typical kidney disease risk factors. While it is generally accepted that environmental exposures contribute to MeN, we hypothesized that there was also an important genetic component. We performed a genome-wide association study comparing individuals...

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PMID: 39585978
DOI: 10.1073/pnas.2404848121
PMCID: PMC11626114

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