Article
Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus.
PLoS pathogens - 1 Nov 2024
Durrant Rowan, Cobbold Christina A, Brunker Kirstyn, Campbell Kathryn, Dushoff Jonathan, Ferguson Elaine A, Jaswant Gurdeep, Lugelo Ahmed, Lushasi Kennedy, Sikana Lwitiko, Hampson Katie
Abstract excerpt
The molecular clock hypothesis assumes that mutations accumulate on an organism's genome at a constant rate over time, but this assumption does not always hold true. While modelling approaches exist to accommodate deviations from a strict molecular clock, assumptions about rate variation may not fully represent the underlying evolutionary processes. There is considerable variability in rabies virus (RABV)...
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