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Article

Assessing the causal association between celiac disease and Alzheimer disease and frontotemporal dementia: A bidirectional Mendelian randomization approach.

Medicine - 17 Oct 2025

Liu Yu, Zhang Hongmei

Abstract excerpt

This study aimed to investigate the bidirectional causal relationship between celiac disease (CD) and the risk of Alzheimer disease (AD) or frontotemporal dementia (FTD) using Mendelian randomization (MR), in order to clarify prior inconsistent findings. We analyzed summary-level genome-wide association study (GWAS) data for CD, AD, and FTD. Single-nucleotide polymorphisms (SNPs) strongly associated with each...

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Topics

Humans
Alzheimer Disease
Frontotemporal Dementia
Mendelian Randomization Analysis
Celiac Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Source

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Identifiers

PMID: 41189247
DOI: 10.1097/MD.0000000000045059
PMCID: PMC12537132

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