Mode of injury and level of synovitis alter inflammatory chondrocyte gene expression and associated pathways

Abstract excerpt

Although various joint injuries result in post-traumatic osteoarthritis (PTOA), differences in chondrocyte response to specific injuries, such as blunt compression or fracture, are unclear. Furthermore, the role of underlying joint inflammation, or synovitis, is often not considered. We investigated how injury mechanisms and underlying synovitis affect chondrocyte gene expression using osteochondral injury models...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammatory mediators and NSAID effects
• Share to Knee injuries and reconstruction techniques
• Share to Osteoarthritis Treatment and Mechanisms