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Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust

15 Nov 2024

Abstract excerpt

• Exposomics of household dust revealed several significant chemicals of interest. • Chemical replacements Bisphenol S (BPS) and PFBuS may modify LRRK2 penetrance. • BPS negatively impacted mitochondria in dopaminergic neuron-enriched cultures. • Benzothiazoles may be degraded by Pseudomonas spp. identified by metagenomics. • Lipid species were altered in the serum of the PD+/LRRK2+ individuals vs controls....

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PMID: 39571299
DOI: 10.1016/j.envint.2024.109151

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