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Article

Association between proton pump inhibitors and dementia risk: a Mendelian randomization study.

Scientific reports - 19 Nov 2024

Xie Kexin, Li Jing, Tang Chengwei, Huang Zhiyin, Chen Ming

Abstract excerpt

Numerous observational studies suggest associations between proton pump inhibitors (PPIs) and dementia, but causal relationships remain uncertain. Using large-scale genome-wide association study (GWAS) data, we performed univariable Mendelian randomization (UVMR) analysis to assess the causality between five PPI types, and all-cause dementia and its five subtypes. Confounders were controlled through multivariable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39562663
DOI: 10.1038/s41598-024-79821-1
PMCID: PMC11576989

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