Article

Relationship Between Neurodegenerative Diseases and Proton Pump Inhibitors Using Bioinformatics

2025-08-21

Abstract excerpt

Proton pump inhibitors (PPIs) are a class of drugs used for the treatment of acid-related diseases by inhibiting gastric acid secretion. Although PPIs are considered safe and clinically beneficial in the short term, mounting evidence raises safety concerns about the long-term use of PPIs. Alzheimer’s disease (AD) is the most common form and cause of dementia and is one of the biggest public health challenges among...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a645f474-6d69-5d46-99d8-8546519a6fe1
DOI: 10.20944/preprints202508.1592.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Relationship Between Neurodegenerative Diseases and Proton Pump Inhibitors Using BioinformaticsDOI 10.20944/preprints202508.1592.v1Read

Associations between proton pump inhibitors and Alzheimer’s disease: A nested case-control study using a Korean nationwide health screening cohortSemantic proximity Read

Unveiling disulfidptosis-related biomarkers and predicting drugs in Alzheimer’s diseaseSemantic proximity Read

Association between proton pump inhibitors and dementia risk: a Mendelian randomization study.Semantic proximity Read

Potential therapeutic targets for Alzheimer's disease and their association with Helicobacter pylori were analyzed based on the data of H. pylori-positive miRNA and Alzheimer's disease mRNA chips in the databaseSemantic proximity Read

Gastrointestinal Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study in 352,463 Middle-Aged AdultsSemantic proximity Read

Insulin growth factor binding protein 7 is a novel target to treat dementiaSemantic proximity Read

Drug Repurposing for Alzheimer’s Disease based on Protein-Protein Interaction NetworkSemantic proximity Read

Repurposing the Memory-promoting Meclofenoxate Hydrochloride as a Treatment for Parkinson‘s Disease through Integrative Multi-omics analysisSemantic proximity Read

Network Pharmacology and molecular docking approach to unveil the mechanism of <i>Hypericum perforatum</i> in the management of Alzheimer’s disorderSemantic proximity Read

Drug Repurposing for Alzheimer’s Disease Based on Protein‐Protein Interaction NetworkSemantic proximity Read

Will Proton Pump Inhibitors Lead to a Higher Risk of COVID-19 Infection and Progression to Severe Disease? A Meta-analysisSemantic proximity Read

Eradication of Helicobacter Pylori May Be Associated With the Incidence of Alzheimer’s Disease in Diabetes Mellitus PatientsSemantic proximity Read