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Article

MIR218 polygenic risk score is associated with cognitive function and neurochemical metabolites among patients with depressed bipolar disorders.

Journal of affective disorders - 15 Feb 2025

Zhang Jianzhao, Zhong Shuming, Lai Shunkai, Zhang Yiliang, Chen Guanmao, Huang Dong, Yan Shuya, Chen Pan, Lu Xiaodan, Yin Jie, Chen Chao, Wang Ying, Jia Yanbin

Abstract excerpt

BACKGROUNDS: Evidence from animal and population studies has consistently revealed that microRNA 218 (MIR218) is involved in susceptibility to depression and cognitive functions. Nevertheless, few studies have evaluated the association between MIR218 and clinical features in patients with depressed bipolar disorder (BD). METHODS: A total of 66 patients with depressed BD and 49 healthy controls (HCs) were...

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PMID: 39561923
DOI: 10.1016/j.jad.2024.11.046

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