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Article

Ciliary genes are down-regulated in bronchial tissue of primary ciliary dyskinesia patients.

PloS one - 1 Jan 2014

Geremek Maciej, Ziętkiewicz Ewa, Bruinenberg Marcel, Franke Lude, Pogorzelski Andrzej, Wijmenga Cisca, Witt Michał

Abstract excerpt

Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disease characterized by recurrent respiratory tract infections, sinusitis, bronchiectasis and male infertility. The pulmonary phenotype in PCD is caused by the impaired motility of cilia in the respiratory epithelium, due to ultrastructural defects of these organelles. We hypothesized that defects of multi-protein ciliary complexes should be...

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Identifiers

PMID: 24516614
DOI: 10.1371/journal.pone.0088216
PMCID: PMC3916409

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